What do you call the drugs that bind to the receptor site and inhibit its natural function?

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**Solution:**

1. **Antagonists** are drugs that bind to receptor sites and block or inhibit the receptor's natural function.

2. **Agonists** bind to receptors and activate them, mimicking the natural ligand's effect.

3. **Antidepressants** are drugs used to treat depression but do not necessarily inhibit receptor function by binding as antagonists.

4. **Depressants** slow down the central nervous system but are not defined by receptor antagonism.

**Answer:** Antagonists

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