Select the most appropriate option that can substitute the underlined segment in the given sentence: My cousin works day and night to achieve success in life.

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The phrase 'day and night' means continuously or all the time. The idiom 'around the clock' means the same, i.e., working continuously without stopping. The other options do not convey this meaning: 'great dealing' is unrelated, 'vale of tears' means a world full of sorrow, and 'a handful' means something difficult to manage. Hence, 'around the clock' is the most appropriate substitution.

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