Charcot-Marie-Tooth disease is caused by duplication of the peripheral myelin protein-22 (PMP22) gene on which chromosome?

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**Solution:**

1. Charcot-Marie-Tooth (CMT) disease is a genetic disorder affecting the peripheral nervous system.

2. The disease is caused by a duplication of the peripheral myelin protein-22 (PMP22) gene.

3. This gene duplication occurs specifically on chromosome 17.

4. The disorder results in progressive muscle weakness and wasting, mainly in the feet, legs, and hands.

5. CMT is inherited in an autosomal dominant manner, meaning a single copy of the mutated gene can cause the disease.

**Additional Information:**
- Chromosome 21 is known for its association with Down syndrome.
- Chromosome 15 is linked to disorders such as Prader-Willi and Angelman syndromes.
- Chromosome 8 is related to other genetic conditions but not CMT.

**Answer:** chromosome 17

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